The Dekati® Smoking Machine is a versatile system for taking and diluting controlled puffs with adjustable volumes and profiles. Repeatable and adjustable puffs are important for characterizing and developing electronic cigarettes and other inhalable aerosol generators. The Dekati® Smoking Machine is developed to allow real-time particle mass and size distribution measurements even from single puffs when combined with an aerosol spectrometer such as the Dekati® High Resolution ELPI®+.